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Environment/Versions PX3-400GQ-T2 DX3-400GQ-T2 Answer Yes, but only in the latest releases: Seems that around 5.16 release (November 2020 release) PX3/DX3 cards which support NRZ card were released Need to set the card to STC-NRZ Mode performance mode under port level - General Tab and then hit APPLY ​​​​​​​ Prior to 5.13 the cards only supported PAM 4 encoding while QSFP28 requires 25 GB per lane NRZ encoding     Please refer to the following KB that may be of your interest: FAQ19784 - Spirent TestCenter: Can a QSFP28 interconnect be used in a PX3-400G port in 100G NRZ mode? FAQ20058 - Spirent TestCenter: What is the difference between QSFP28, QSFP-DD, and QSFP56 transceivers?